Elevated cerebellar glucose metabolism in microvascular white matter disease: normal aging and Alzheimer's disease.

Publication Type	Academic Article
Authors	Klinger A, de Leon M, George A, Miller J, Wolf A
Journal	J Cereb Blood Flow Metab
Volume	8
Issue	3
Pagination	433-5
Date Published	06/01/1988
ISSN	0271-678X
Keywords	Aging, Alzheimer Disease, Cerebellum, Glucose
Abstract	Young normal, elderly, and clinically diagnosed Alzheimer disease subjects who had undergone positron emission tomography (PET) and computed tomography (CT) examinations were studied to determine the effect of periventricular white matter lesions on cerebellar glucose metabolic rates. PET-determined cerebellar metabolic rates were elevated in subjects with periventricular white matter lesions. These results suggest the cautious use of cortical-to-cerebellar ratios in future PET or single-photon-emission CT (SPECT) studies.
DOI	10.1038/jcbfm.1988.80
PubMed ID	3259243