Establishing Minimal Clinically Important Differences for the Cognitive and Linguistic Scale (CALS) in Pediatric Neurorehabilitation.

Publication Type	Academic Article
Authors	Svingos A, Forsyth R, Alkhoury L, Slomine B, Suskauer S, Watson W, Blackwell L, Shah S
Journal	Arch Phys Med Rehabil
Date Published	01/06/2025
ISSN	1532-821X
Abstract	The Cognitive and Linguistic Scale (CALS) was developed to serially monitor cognitive recovery of children and young people after severe acquired brain injury (ABI), during inpatient rehabilitation. The CALS can be used to derive Cognitive Ability Estimates (CAE) which are Rasch-propertied (unidimensional, interval-scale) and therefore may be ideally applied for use in research including within the context of clinical trials. Here, we used established statistical distribution-based and expert consensus-based methods to estimate the Minimal Clinically Important Difference (MCID) for CAE derived from the CALS. Together, results suggest a MCID of approximately 4-7 CAE units. These data can be used to aid in the design and interpretation of clinical studies proposing to use the CALS CAE as an outcome measure.
DOI	10.1016/j.apmr.2024.12.020
PubMed ID	39778788