Publication Type	Academic Article
Authors	Alexopoulos G, Murphy C, Gunning-Dixon F, Kalayam B, Katz R, Kanellopoulos D, Etwaroo G, Klimstra S, Foxe J
Journal	Neuroreport
Volume	18
Issue	3
Pagination	217-21
Date Published	02/12/2007
ISSN	0959-4965
Keywords	Aging, Antidepressive Agents, Depressive Disorder, Major, Emotions, Evoked Potentials, Gyrus Cinguli
Abstract	Anterior cingulate integrity may be required for antidepressant response. To assess anterior cingulate processes related to treatment response, we studied error-related negativity and error positivity produced during an emotional go/no-go challenge, a task activating the rostral anterior cingulate. Twelve elderly patients with major depression, treated with escitalopram 10 mg daily, were studied. Patients who remained symptomatic after 8 weeks of treatment had larger error-related negativity and smaller error positivity amplitude compared with patients who achieved remission. The error-related negativity is elicited during conflict detection and the error positivity reflects the emotional reaction to error. Thus, these findings suggest that two distinct conflict-processing functions of the anterior cingulate are important for antidepressant response of geriatric depression.
DOI	10.1097/WNR.0b013e328013ceda
PubMed ID	17314660