Publication Type Academic Article
Authors Alexopoulos G, Murphy C, Gunning-Dixon F, Kalayam B, Katz R, Kanellopoulos D, Etwaroo G, Klimstra S, Foxe J
Journal Neuroreport
Volume 18
Issue 3
Pagination 217-21
Date Published 02/12/2007
ISSN 0959-4965
Keywords Aging, Antidepressive Agents, Depressive Disorder, Major, Emotions, Evoked Potentials, Gyrus Cinguli
Abstract Anterior cingulate integrity may be required for antidepressant response. To assess anterior cingulate processes related to treatment response, we studied error-related negativity and error positivity produced during an emotional go/no-go challenge, a task activating the rostral anterior cingulate. Twelve elderly patients with major depression, treated with escitalopram 10 mg daily, were studied. Patients who remained symptomatic after 8 weeks of treatment had larger error-related negativity and smaller error positivity amplitude compared with patients who achieved remission. The error-related negativity is elicited during conflict detection and the error positivity reflects the emotional reaction to error. Thus, these findings suggest that two distinct conflict-processing functions of the anterior cingulate are important for antidepressant response of geriatric depression.
DOI 10.1097/WNR.0b013e328013ceda
PubMed ID 17314660
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