Event-related potentials in an emotional go/no-go task and remission of geriatric depression.
| Publication Type | Academic Article |
| Authors | Alexopoulos G, Murphy C, Gunning-Dixon F, Kalayam B, Katz R, Kanellopoulos D, Etwaroo G, Klimstra S, Foxe J |
| Journal | Neuroreport |
| Volume | 18 |
| Issue | 3 |
| Pagination | 217-21 |
| Date Published | 02/12/2007 |
| ISSN | 0959-4965 |
| Keywords | Aging, Antidepressive Agents, Depressive Disorder, Major, Emotions, Evoked Potentials, Gyrus Cinguli |
| Abstract | Anterior cingulate integrity may be required for antidepressant response. To assess anterior cingulate processes related to treatment response, we studied error-related negativity and error positivity produced during an emotional go/no-go challenge, a task activating the rostral anterior cingulate. Twelve elderly patients with major depression, treated with escitalopram 10 mg daily, were studied. Patients who remained symptomatic after 8 weeks of treatment had larger error-related negativity and smaller error positivity amplitude compared with patients who achieved remission. The error-related negativity is elicited during conflict detection and the error positivity reflects the emotional reaction to error. Thus, these findings suggest that two distinct conflict-processing functions of the anterior cingulate are important for antidepressant response of geriatric depression. |
| DOI | 10.1097/WNR.0b013e328013ceda |
| PubMed ID | 17314660 |