Giant cell tumor of the spine.

Publication Type	Review
Authors	Luther N, Bilsky M, Härtl R
Journal	Neurosurg Clin N Am
Volume	19
Issue	1
Pagination	49-55
Date Published	01/01/2008
ISSN	1558-1349
Keywords	Giant Cell Tumor of Bone, Spinal Neoplasms, Spine
Abstract	Giant cell tumors are benign but locally aggressive neoplasms that typically affect the extremities. When involving the spine, the tumors occur predominantly in the sacrum. Gross total resection of the tumor with wide margins yields good results in terms of survival. However, it carries a significant potential for morbidity and disability. Subtotal resection with adjuvant radiation carries a risk for recurrence or, more concerning, sarcomatous malignant transformation. Endovascular tumor embolizations have also been attempted to control unresectable tumors, and have been performed with moderate degrees of success. Outcomes are analyzed outcomes following surgery, radiation therapy, and tumor embolization.
DOI	10.1016/j.nec.2007.09.009
PubMed ID	18156047