Publication Type Review
Authors Luther N, Bilsky M, Härtl R
Journal Neurosurg Clin N Am
Volume 19
Issue 1
Pagination 49-55
Date Published 01/01/2008
ISSN 1558-1349
Keywords Giant Cell Tumor of Bone, Spinal Neoplasms, Spine
Abstract Giant cell tumors are benign but locally aggressive neoplasms that typically affect the extremities. When involving the spine, the tumors occur predominantly in the sacrum. Gross total resection of the tumor with wide margins yields good results in terms of survival. However, it carries a significant potential for morbidity and disability. Subtotal resection with adjuvant radiation carries a risk for recurrence or, more concerning, sarcomatous malignant transformation. Endovascular tumor embolizations have also been attempted to control unresectable tumors, and have been performed with moderate degrees of success. Outcomes are analyzed outcomes following surgery, radiation therapy, and tumor embolization.
DOI 10.1016/j.nec.2007.09.009
PubMed ID 18156047
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