Publication Type Academic Article
Authors Dimov A, Nguyen T, Spincemaille P, Sweeney E, Zinger N, Kovanlikaya I, Kopell B, Gauthier S, Wang Y
Journal J Neuroimaging
Volume 32
Issue 1
Pagination 141-147
Date Published 09/04/2021
ISSN 1552-6569
Keywords Image Processing, Computer-Assisted, Magnetic Resonance Imaging
Abstract BACKGROUND AND PURPOSE: The objective ofthis study was to demonstrate a global cerebrospinal fluid (CSF) method for a consistent and automated zero referencing of brain quantitative susceptibility mapping (QSM). METHODS: R RESULTS: In scan-rescan experiments, global CSF regularization provided more consistent CSF volume as well as higher repeatability of QSM measurements than ventricular CSF regularization with a smaller bias: -2.7 parts per billion (ppb) versus -0.13 ppb (t-test p<0.05) and a narrower 95% limits of agreement: [-7.25, 6.99] ppb versus [-16.60, 11.19 ppb] (f-test p<0.05). In PD and MS patients, global CSF regularization reduced smoothly varying shadow artifacts and significantly improved the QSM quality score (p<0.001). CONCLUSIONS: The proposed whole brain CSF method for QSM zero referencing improves repeatability and image quality of brain QSM compared to the ventricular CSF method.
DOI 10.1111/jon.12923
PubMed ID 34480496
PubMed Central ID PMC8752493
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