Herpes Simplex Oncolytic Viral Therapy for Malignant Glioma and Mechanisms of Delivery.
| Publication Type | Review |
| Authors | Erickson N, Stavarache M, Tekedereli I, Kaplitt M, Markert J |
| Journal | World Neurosurg |
| Volume | 194 |
| Pagination | 123595 |
| Date Published | 01/23/2025 |
| ISSN | 1878-8769 |
| Abstract | The authors present a comprehensive review on the history and development of oncolytic herpes simplex viral therapies for malignant glioma with a focus on mechanisms of delivery in prior and ongoing clinical trials. This review highlights the advancements made with regard to delivering these therapies to a highly complex immunologic environment in the setting of the blood-brain and blood-tumor barrier in a safe and effective manner. |
| DOI | 10.1016/j.wneu.2024.123595 |
| PubMed ID | 39710201 |