Herpes Simplex Oncolytic Viral Therapy for Malignant Glioma and Mechanisms of Delivery.

Publication Type Review
Authors Erickson N, Stavarache M, Ibrahim T, Kaplitt M, Markert J
Journal World Neurosurg
Pagination 123595
Date Published 12/20/2024
ISSN 1878-8769
Abstract The authors present a comprehensive review on the history and development of oncolytic herpes simplex viral therapies for malignant glioma with a focus on mechanisms of delivery in prior and ongoing clinical trials. This review highlights the advancements made with regard to delivering these therapies to a highly complex immunologic environment in the setting of the blood brain and blood tumor barrier in a safe and effective manner.
DOI 10.1016/j.wneu.2024.123595
PubMed ID 39710201
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