Publication Type Academic Article
Authors Golomb J, Kluger A, de Leon M, Ferris S, Mittelman M, Cohen J, George A
Journal Neurology
Volume 47
Issue 3
Pagination 810-3
Date Published 09/01/1996
ISSN 0028-3878
Keywords Aging, Hippocampus, Memory
Abstract Hippocampal formation (HF) atrophy, although common in normal aging, has unknown clinical consequences. We used MRI to derive HF size measurements at baseline on 44 cognitively normal older adults entering a longitudinal study of memory function (mean age = 68.4 years, mean follow-up = 3.8 years). Only one subject became demented at follow-up. Multiple regression analyses controlling for age, gender, education, and diffuse cerebral atrophy revealed that HF size significantly predicted longitudinal change on memory tests previously found sensitive to decline in normal aging. These results indicate HF atrophy may be a risk factor for accelerated memory dysfunction in normal aging.
DOI 10.1212/wnl.47.3.810
PubMed ID 8797485
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