Hippocampal formation size predicts declining memory performance in normal aging.

Publication Type	Academic Article
Authors	Golomb J, Kluger A, de Leon M, Ferris S, Mittelman M, Cohen J, George A
Journal	Neurology
Volume	47
Issue	3
Pagination	810-3
Date Published	09/01/1996
ISSN	0028-3878
Keywords	Aging, Hippocampus, Memory
Abstract	Hippocampal formation (HF) atrophy, although common in normal aging, has unknown clinical consequences. We used MRI to derive HF size measurements at baseline on 44 cognitively normal older adults entering a longitudinal study of memory function (mean age = 68.4 years, mean follow-up = 3.8 years). Only one subject became demented at follow-up. Multiple regression analyses controlling for age, gender, education, and diffuse cerebral atrophy revealed that HF size significantly predicted longitudinal change on memory tests previously found sensitive to decline in normal aging. These results indicate HF atrophy may be a risk factor for accelerated memory dysfunction in normal aging.
DOI	10.1212/wnl.47.3.810
PubMed ID	8797485