Publication Type Academic Article
Authors Gu Z, Jamison K, Sabuncu M, Kuceyeski A
Journal Commun Biol
Volume 6
Issue 1
Pagination 1076
Date Published 10/23/2023
ISSN 2399-3642
Keywords Brain, Temporal Lobe
Abstract Understanding how human brains interpret and process information is important. Here, we investigated the selectivity and inter-individual differences in human brain responses to images via functional MRI. In our first experiment, we found that images predicted to achieve maximal activations using a group level encoding model evoke higher responses than images predicted to achieve average activations, and the activation gain is positively associated with the encoding model accuracy. Furthermore, anterior temporal lobe face area (aTLfaces) and fusiform body area 1 had higher activation in response to maximal synthetic images compared to maximal natural images. In our second experiment, we found that synthetic images derived using a personalized encoding model elicited higher responses compared to synthetic images from group-level or other subjects' encoding models. The finding of aTLfaces favoring synthetic images than natural images was also replicated. Our results indicate the possibility of using data-driven and generative approaches to modulate macro-scale brain region responses and probe inter-individual differences in and functional specialization of the human visual system.
DOI 10.1038/s42003-023-05440-7
PubMed ID 37872319
PubMed Central ID PMC10593916
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