Imaging of cerebrovascular reserve and oxygenation in Moyamoya disease.
| Publication Type | Academic Article |
| Authors | Ni W, Christen T, Rosenberg J, Zun Z, Moseley M, Zaharchuk G |
| Journal | J Cereb Blood Flow Metab |
| Volume | 37 |
| Issue | 4 |
| Pagination | 1213-1222 |
| Date Published | 01/01/2016 |
| ISSN | 1559-7016 |
| Keywords | Brain, Cerebrovascular Circulation, Image Interpretation, Computer-Assisted, Magnetic Resonance Angiography, Moyamoya Disease, Oxygen |
| Abstract | This study aimed to determine whether measurements of cerebrovascular reserve and oxygenation, assessed with spin relaxation rate R2', yield similar information about pathology in pre-operative Moyamoya disease patients, and to assess whether R2' is a better measure of oxygenation than other proposed markers, such as R2* and R2. Twenty-five pre-operative Moyamoya disease patients were scanned at 3.0T with acetazolamide challenge. Cerebral blood flow mapping with multi-delay arterial spin labeling, and R2*, R2, and R2' mapping with Gradient-Echo Sampling of Free Induction Decay and Echo were performed. No baseline cerebral blood flow difference was found between angiographically abnormal and normal regions (49 ± 12 vs. 48 ± 11 mL/100 g/min, p = 0.44). However, baseline R2' differed between these regions (3.2 ± 0.7 vs. 2.9 ± 0.6 s-1, p < 0.001), indicating reduced oxygenation in abnormal regions. Cerebrovascular reserve was lower in angiographically abnormal regions (21 ± 38 vs. 41 ± 26%, p = 0.001). All regions showed trend toward significantly improved oxygenation post-acetazolamide. Regions with poorer cerebrovascular reserve had lower baseline oxygenation (Kendall's τ = -0.24, p = 0.003). A number of angiographically abnormal regions demonstrated preserved cerebrovascular reserve, likely due to the presence of collaterals. Finally, of the concurrently measured relaxation rates, R2' was superior for oxygenation assessment. |
| DOI | 10.1177/0271678X16651088 |
| PubMed ID | 27207169 |
| PubMed Central ID | PMC5453445 |