Intravoxel incoherent motion diffusion-weighted MR imaging of breast cancer: association with histopathological features and subtypes.

Publication Type	Academic Article
Authors	Kim Y, Ko K, Kim D, Min C, Kim S, Joo J, Park B
Journal	Br J Radiol
Volume	89
Issue	1063
Pagination	20160140
Date Published	05/20/2016
ISSN	1748-880X
Keywords	Breast Neoplasms, Diffusion Magnetic Resonance Imaging
Abstract	OBJECTIVE: To evaluate the associations between intravoxel incoherent motion (IVIM)-derived parameters and histopathological features and subtypes of breast cancer. METHODS: Pre-operative MRI from 275 patients with unilateral breast cancer was analyzed. The apparent diffusion coefficient (ADC) and IVIM parameters [tissue diffusion coefficient (Dt), perfusion fraction (fp) and pseudodiffusion coefficient] were obtained from cancer and normal tissue using diffusion-weighted imaging with b-values of 0, 30, 70, 100, 150, 200, 300, 400, 500 and 800 s mm(-2). We then compared the IVIM parameters of tumours with different histopathological features and subtypes. RESULTS: The ADC and Dt were lower and fp was higher in cancers than in normal tissues (p < 0.001). The Dt was lower in high Ki-67 cancer than in low Ki-67 cancer (p = 0.019), whereas ADC showed no significant difference (p = 0.309). Luminal B [human epidermal growth factor receptor 2 (HER2)-negative] cancer showed lower ADC (p = 0.003) and Dt (p = 0.001) than other types. CONCLUSION: We found low tissue diffusivity in high Ki-67 cancer and luminal B (HER2-negative) cancer using IVIM imaging. ADVANCES IN KNOWLEDGE: Low tissue diffusivity is more clearly shown in high Ki-67 tumours and luminal B (HER2-negative) tumours with the IVIM model.
DOI	10.1259/bjr.20160140
PubMed ID	27197744
PubMed Central ID	PMC5257327