Publication Type Review
Authors Dunlop K, Talishinsky A, Liston C
Journal Curr Psychiatry Rep
Volume 21
Issue 9
Pagination 87
Date Published 08/13/2019
ISSN 1535-1645
Keywords Antidepressive Agents, Biomarkers, Brain, Depressive Disorder, Major
Abstract PURPOSE OF REVIEW: Poor treatment response is a hallmark of major depressive disorder. To tackle this problem, recent neuroimaging studies have sought to characterize antidepressant response in terms of pretreatment differences in intrinsic functional brain networks. Our aim is to review recent studies that predict antidepressant response using intrinsic network connectivity. We discuss current methodological limitations and directions for future antidepressant biomarker studies. RECENT FINDINGS: Functional connectivity stemming from the subgenual and rostral anterior cingulate has shown particular consistency in predicting antidepressant response. Differences in this connectivity may prove fruitful in differentiating treatment responders to many antidepressant interventions. Future biomarker studies should integrate biological MDD subtypes to address the disorder's inherent clinical heterogeneity. These clinical and scientific advancements have the potential to address this population marked by limited treatment response. Methodological considerations, including patient selection, response criteria, and model overfitting, will require future investigation to ensure that biomarkers generalize for prospective prediction of treatment response.
DOI 10.1007/s11920-019-1072-6
PubMed ID 31410661
PubMed Central ID PMC6692448
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