Publication Type | Academic Article |
Authors | Suehiro M, Vallabhajosula S, Goldsmith S, Ballon D |
Journal | Appl Radiat Isot |
Volume | 65 |
Issue | 12 |
Pagination | 1350-8 |
Date Published | 07/25/2007 |
ISSN | 0969-8043 |
Keywords | Dideoxynucleosides, Fluorine Radioisotopes, Radiopharmaceuticals |
Abstract | The role of the base in the synthesis of 3'-deoxy-3'-[18F]fluorothymidine, [18F]FLT, via nucleophilic substitution of the nosyl group with [18F]fluoride was investigated. The rate of 18F-incorporation into the molecule dramatically changed as a function of the precursor-to-base ratio. In the presence of excess base, the precursor was consumed by elimination before substitution was complete. When the precursor-to-base ratio was optimal, an overall [18F]FLT yield of 30-40% was achieved even if the precursor amount was as small as 8-13 mg. |
DOI | 10.1016/j.apradiso.2007.07.013 |
PubMed ID | 17919915 |