Publication Type Academic Article
Authors Azevedo E, Tan B, Pomeranz L, Ivan V, Fetcho R, Schneeberger M, Doerig K, Liston C, Friedman J, Stern S
Journal Elife
Volume 9
Date Published 09/07/2020
ISSN 2050-084X
Keywords Eating, Escape Reaction, Limbic System, Neurons
Abstract Stress has pleiotropic physiologic effects, but the neural circuits linking stress to these responses are not well understood. Here, we describe a novel population of lateral septum neurons expressing neurotensin (LSNts) in mice that are selectively tuned to specific types of stress. LSNts neurons increase their activity during active escape, responding to stress when flight is a viable option, but not when associated with freezing or immobility. Chemogenetic activation of LSNts neurons decreases food intake and body weight, without altering locomotion and anxiety. LSNts neurons co-express several molecules including Glp1r (glucagon-like peptide one receptor) and manipulations of Glp1r signaling in the LS recapitulates the behavioral effects of LSNts activation. Activation of LSNts terminals in the lateral hypothalamus (LH) also decreases food intake. These results show that LSNts neurons are selectively tuned to active escape stress and can reduce food consumption via effects on hypothalamic pathways.
DOI 10.7554/eLife.58894
PubMed ID 32894221
PubMed Central ID PMC7476759
Back to Top