Publication Type Academic Article
Authors Kang Y, Pandya S, Zinger N, Michaelson N, Gauthier S
Journal Ann Clin Transl Neurol
Volume 8
Issue 8
Pagination 1755-1759
Date Published 07/26/2021
ISSN 2328-9503
Keywords Gray Matter, Multiple Sclerosis, Chronic Progressive, Receptors, GABA, White Matter
Abstract The objective of this pilot study was to assess a 2-year change in innate immune burden in 15 progressive multiple sclerosis (MS) patients using PK11195-PET. Sixteen age-matched healthy controls (HC) were included for baseline comparison. PK11195 uptake was higher in MS patients compared to HC within normal-appearing white matter (NAWM) and multiple gray matter regions. In patients, PK11195 uptake increased in NAWM (p = 0.01), cortex (p = 0.04), thalamus (p = 0.04), and putamen (p = 0.02) at 12 months. Among patients remaining at 24 months, there was no further increase in PK11195. Our data suggest that innate immune activity may increase over time in patients with progressive MS.
DOI 10.1002/acn3.51431
PubMed ID 34310086
PubMed Central ID PMC8351399
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