Longitudinal change in TSPO PET imaging in progressive multiple sclerosis.

Publication Type	Academic Article
Authors	Kang Y, Pandya S, Zinger N, Michaelson N, Gauthier S
Journal	Ann Clin Transl Neurol
Volume	8
Issue	8
Pagination	1755-1759
Date Published	07/26/2021
ISSN	2328-9503
Keywords	Gray Matter, Multiple Sclerosis, Chronic Progressive, Receptors, GABA, White Matter
Abstract	The objective of this pilot study was to assess a 2-year change in innate immune burden in 15 progressive multiple sclerosis (MS) patients using PK11195-PET. Sixteen age-matched healthy controls (HC) were included for baseline comparison. PK11195 uptake was higher in MS patients compared to HC within normal-appearing white matter (NAWM) and multiple gray matter regions. In patients, PK11195 uptake increased in NAWM (p = 0.01), cortex (p = 0.04), thalamus (p = 0.04), and putamen (p = 0.02) at 12 months. Among patients remaining at 24 months, there was no further increase in PK11195. Our data suggest that innate immune activity may increase over time in patients with progressive MS.
DOI	10.1002/acn3.51431
PubMed ID	34310086
PubMed Central ID	PMC8351399