Publication Type | Academic Article |
Authors | Berti V, Walters M, Sterling J, Quinn C, Logue M, Andrews R, Matthews D, Osorio R, Pupi A, Vallabhajosula S, Isaacson R, de Leon M, Mosconi L |
Journal | Neurology |
Volume | 90 |
Issue | 20 |
Pagination | e1789-e1798 |
Date Published | 04/13/2018 |
ISSN | 1526-632X |
Keywords | Alzheimer Disease, Brain, Diet, Mediterranean |
Abstract | OBJECTIVE: To examine in a 3-year brain imaging study the effects of higher vs lower adherence to a Mediterranean-style diet (MeDi) on Alzheimer disease (AD) biomarker changes (brain β-amyloid load via 11C-Pittsburgh compound B [PiB] PET and neurodegeneration via 18F-fluorodeoxyglucose [FDG] PET and structural MRI) in midlife. METHODS: Seventy 30- to 60-year-old cognitively normal participants with clinical, neuropsychological, and dietary examinations and imaging biomarkers at least 2 years apart were examined. These included 34 participants with higher (MeDi+) and 36 with lower (MeDi-) MeDi adherence. Statistical parametric mapping and volumes of interest were used to compare AD biomarkers between groups at cross section and longitudinally. RESULTS: MeDi groups were comparable for clinical and neuropsychological measures. At baseline, compared to the MeDi+ group, the MeDi- group showed reduced FDG-PET glucose metabolism (CMRglc) and higher PiB-PET deposition in AD-affected regions (p < 0.001). Longitudinally, the MeDi--group showed CMRglc declines and PiB increases in these regions, which were greater than those in the MeDi+ group (pinteraction < 0.001). No effects were observed on MRI. Higher MeDi adherence was estimated to provide 1.5 to 3.5 years of protection against AD. CONCLUSION: Lower MeDi adherence was associated with progressive AD biomarker abnormalities in middle-aged adults. These data support further investigation of dietary interventions for protection against brain aging and AD. |
DOI | 10.1212/WNL.0000000000005527 |
PubMed ID | 29653991 |
PubMed Central ID | PMC5957301 |