Publication Type Academic Article
Authors Glodzik L, King K, Gonen O, Liu S, De Santi S, de Leon M
Journal Prog Neuropsychopharmacol Biol Psychiatry
Volume 32
Issue 4
Pagination 1005-12
Date Published 02/07/2008
ISSN 0278-5846
Keywords Excitatory Amino Acid Antagonists, Glutamic Acid, Hippocampus, Memantine
Abstract Glutamate (Glu) is associated with excitotoxic cell damage. Memantine modulates the glutamate induced excitotoxicity in Alzheimer's disease (AD). No information is available as to the influence of memantine on in vivo brain glutamate levels. Hippocampal Glu levels were measured in cognitively impaired and normal individuals (n=10) before and after 6 months of memantine treatment, using three dimensional high spatial resolution (0.5 cm(3) voxels) proton magnetic resonance spectroscopy at 3 T. These measurements were also repeated in a non-treated cognitively normal group (n=6). Treatment with memantine decreased Glu/Cr (creatine) ratio in the left hippocampal region. Memantine reduced hippocampal glutamate levels, which may be consistent with its anti-excitotoxic property.
DOI 10.1016/j.pnpbp.2008.01.016
PubMed ID 18343551
PubMed Central ID PMC2789554
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