Multimodality Imaging in Primary Progressive Aphasia.

Publication Type	Review
Authors	Roytman M, Chiang G, Gordon M, Franceschi A
Journal	AJNR Am J Neuroradiol
Volume	43
Issue	9
Pagination	1230-1243
Date Published	08/25/2022
ISSN	1936-959X
Keywords	Aphasia, Primary Progressive
Abstract	Primary progressive aphasia is a clinically and neuropathologically heterogeneous group of progressive neurodegenerative disorders, characterized by language-predominant impairment and commonly associated with atrophy of the dominant language hemisphere. While this clinical entity has been recognized dating back to the 19th century, important advances have been made in defining our current understanding of primary progressive aphasia, with 3 recognized subtypes to date: logopenic variant, semantic variant, and nonfluent/agrammatic variant. Given the ongoing progress in our understanding of the neurobiology and genomics of these rare neurodegenerative conditions, accurate imaging diagnoses are of the utmost importance and carry implications for future therapeutic triaging. This review covers the diverse spectrum of primary progressive aphasia and its multimodal imaging features, including structural, functional, and molecular neuroimaging findings; it also highlights currently recognized diagnostic criteria, clinical presentations, histopathologic biomarkers, and treatment options of these 3 primary progressive aphasia subtypes.
DOI	10.3174/ajnr.A7613
PubMed ID	36007947
PubMed Central ID	PMC9451618