Publication Type Review
Authors Butler T, Weisholtz D, Isenberg N, Harding E, Epstein J, Stern E, Silbersweig D
Journal Epilepsy Behav
Volume 23
Issue 2
Pagination 113-22
Date Published 12/29/2011
ISSN 1525-5069
Keywords Epilepsy, Frontal Lobe, Limbic System, Neuroimaging, Psychotic Disorders
Abstract Psychosis is a devastating, prevalent condition considered to involve dysfunction of frontal and medial temporal limbic brain regions as key nodes in distributed brain networks involved in emotional regulation. The psychoses of epilepsy represent an important, though understudied, model relevant to understanding the pathophysiology of psychosis in general. In this review, we (1) discuss the classification of epilepsy-related psychoses and relevant neuroimaging and other studies; (2) review structural and functional neuroimaging studies of schizophrenia focusing on evidence of frontal-limbic dysfunction; (3) report our laboratory's PET, fMRI, and electrophysiological findings; (4) describe a theoretical framework in which frontal hypoactivity and intermittent medial temporal hyperactivity play a critical role in the etiopathology of psychosis both associated and unassociated with epilepsy; and (5) suggest avenues for future research.
DOI 10.1016/j.yebeh.2011.11.004
PubMed ID 22209327
PubMed Central ID PMC3339259
Back to Top