Neuronal and volume loss in CA1 of the hippocampal formation uniquely predicts duration and severity of Alzheimer disease.

Publication Type	Academic Article
Authors	Bobinski M, de Leon M, Tarnawski M, Wegiel J, Reisberg B, Miller D, Wisniewski H
Journal	Brain Res
Volume	805
Issue	1-2
Pagination	267-9
Date Published	09/14/1998
ISSN	0006-8993
Keywords	Alzheimer Disease, Hippocampus, Neurons
Abstract	In a series of multiple regression models predicting either duration or severity of Alzheimer disease (AD) patients, significant linear correlations were found consistently for the volume of CA1, the subiculum, and the entorhinal cortex. Similarly, the total number of neurons in CA1, CA4, and the subiculum was correlated significantly with both the duration and the severity of AD. A hierarchical multiple regression model was used to examine whether any of these intercorrelated measures had any unique relationship to disease duration or severity. The results showed that only CA1 demonstrated a unique contribution to the explained variance in predicting duration or severity of AD for volume and for neuronal numbers. These results indicate that in the hippocampal formation, volume and neuronal numbers of CA1 appear to show a unique relationship with clinical measures of AD.
DOI	10.1016/s0006-8993(98)00759-8
PubMed ID	9733982