Publication Type Review
Authors Dyke J, Aaron R
Journal Ann N Y Acad Sci
Volume 1192
Issue 1
Pagination 95-102
Date Published 03/01/2010
ISSN 1749-6632
Keywords Bone and Bones, Magnetic Resonance Angiography, Perfusion Imaging
Abstract Measurement of bone blood flow and perfusion characteristics in a noninvasive and serial manner would be advantageous in assessing revascularization after trauma and the possible risk of avascular necrosis. Many disease states, including osteoporosis, osteoarthritis, and bone neoplasms, result in disturbed bone perfusion. A causal link between bone perfusion and remodeling has shown its importance in sustained healing and regrowth following injury. Measurement of perfusion and permeability within the bone was performed with small and macromolecular contrast media, using dynamic contrast-enhanced magnetic resonance imaging in models of osteoarthritis and the femoral head. Bone blood flow and remodeling was estimated using (18)F-Fluoride positron emission tomography in fracture healing and osteoarthritis. Multimodality assessment of bone blood flow, permeability, and remodeling by using noninvasive imaging techniques may provide information essential in monitoring subsequent rates of healing and response to treatment as well as identifying candidates for additional therapeutic or surgical interventions.
DOI 10.1111/j.1749-6632.2009.05376.x
PubMed ID 20392223
PubMed Central ID PMC2894463
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