Publication Type Review
Authors Schelke M, Hackett K, Chen J, Shih C, Shum J, Montgomery M, Chiang G, Berkowitz C, Seifan A, Krikorian R, Isaacson R
Journal Ann N Y Acad Sci
Volume 1367
Issue 1
Pagination 50-6
Date Published 03/01/2016
ISSN 1749-6632
Keywords Alzheimer Disease, Nutritional Status, Precision Medicine, Risk Reduction Behavior
Abstract Alzheimer's disease (AD) is a major source of morbidity and mortality, with the disease burden expected to rise as the population ages. No disease-modifying agent is currently available, but recent research suggests that nutritional and lifestyle modifications can delay or prevent the onset of AD. However, preventive nutritional interventions are not universally applicable and depend on the clinical profile of the individual patient. This article reviews existing nutritional modalities for AD prevention that act through improvement of insulin resistance, correction of dyslipidemia, and reduction of oxidative stress, and discusses how they may be modified on the basis of individual biomarkers, genetics, and behavior. In addition, we report preliminary results of clinical application of these personalized interventions at the first AD prevention clinic in the United States. The use of these personalized interventions represents an important application of precision medicine techniques for the prevention of AD that can be adopted by clinicians across disciplines.
DOI 10.1111/nyas.13070
PubMed ID 27116241
PubMed Central ID PMC5674531
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