Parkinson's disease spatial covariance pattern: noninvasive quantification with perfusion MRI.
| Publication Type | Academic Article |
| Authors | Ma Y, Huang C, Dyke J, Pan H, Alsop D, Feigin A, Eidelberg D |
| Journal | J Cereb Blood Flow Metab |
| Volume | 30 |
| Issue | 3 |
| Pagination | 505-9 |
| Date Published | 01/06/2010 |
| ISSN | 1559-7016 |
| Keywords | Parkinson Disease |
| Abstract | Parkinson's disease (PD) is associated with elevated expression of a specific disease-related spatial covariance pattern (PDRP) in radiotracer scans of cerebral blood flow and metabolism. In this study, we scanned nine early-stage patients with PD and nine healthy controls using continuous arterial spin labeling (CASL) perfusion magnetic resonance imaging (pMRI). Parkinson's disease-related metabolic pattern expression in CASL pMRI scans was compared with the corresponding (18)F-fluorodeoxyglucose positron emission tomography values. The PDRP expression was abnormally elevated (P<0.01) in patients scanned with either modality, and the two values were highly intercorrelated (P<0.0001). Perfusion MRI methods can be used for accurate quantification of disease-related covariance patterns. |
| DOI | 10.1038/jcbfm.2009.256 |
| PubMed ID | 20051975 |
| PubMed Central ID | PMC2949137 |