Publication Type Academic Article
Authors Ma Y, Huang C, Dyke J, Pan H, Alsop D, Feigin A, Eidelberg D
Journal J Cereb Blood Flow Metab
Volume 30
Issue 3
Pagination 505-9
Date Published 01/06/2010
ISSN 1559-7016
Keywords Parkinson Disease
Abstract Parkinson's disease (PD) is associated with elevated expression of a specific disease-related spatial covariance pattern (PDRP) in radiotracer scans of cerebral blood flow and metabolism. In this study, we scanned nine early-stage patients with PD and nine healthy controls using continuous arterial spin labeling (CASL) perfusion magnetic resonance imaging (pMRI). Parkinson's disease-related metabolic pattern expression in CASL pMRI scans was compared with the corresponding (18)F-fluorodeoxyglucose positron emission tomography values. The PDRP expression was abnormally elevated (P<0.01) in patients scanned with either modality, and the two values were highly intercorrelated (P<0.0001). Perfusion MRI methods can be used for accurate quantification of disease-related covariance patterns.
DOI 10.1038/jcbfm.2009.256
PubMed ID 20051975
PubMed Central ID PMC2949137
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