Weill Cornell Medicine
Citigroup Biomedical Imaging Center
Weill Cornell Medicine
Citigroup Biomedical Imaging Center

Pathophysiology, Assessment, and Management of Post-Stroke Cognitive Impairment, Depression, and Fatigue.

Publication Type Review
Authors Jaywant A, Keenan A
Journal Phys Med Rehabil Clin N Am
Volume 35
Issue 2
Pagination 463-478
Date Published 08/12/2023
ISSN 1558-1381
Keywords Stroke, Cognitive Dysfunction
Abstract Post-stroke cognitive impairment, depression, and fatigue are common, persistent, and disabling. This review summarizes current knowledge on the pathophysiology, assessment, and management of these debilitating neuropsychiatric sequelae of stroke. We briefly review evolving knowledge on the neural mechanisms and risk factors for each condition. We describe patient-reported outcome measures and clinician rating techniques that can be used to assist in screening and comprehensive assessment. We then discuss behavioral and pharmacologic management strategies. Heterogeneity of stroke remains a challenge in management and new research is still needed to optimize and personalize treatments for stroke survivors.
DOI 10.1016/j.pmr.2023.06.028
PubMed ID 38514230
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