Pathophysiology, Assessment, and Management of Post-Stroke Cognitive Impairment, Depression, and Fatigue.

Publication Type	Review
Authors	Jaywant A, Keenan A
Journal	Phys Med Rehabil Clin N Am
Volume	35
Issue	2
Pagination	463-478
Date Published	08/12/2023
ISSN	1558-1381
Keywords	Stroke, Cognitive Dysfunction
Abstract	Post-stroke cognitive impairment, depression, and fatigue are common, persistent, and disabling. This review summarizes current knowledge on the pathophysiology, assessment, and management of these debilitating neuropsychiatric sequelae of stroke. We briefly review evolving knowledge on the neural mechanisms and risk factors for each condition. We describe patient-reported outcome measures and clinician rating techniques that can be used to assist in screening and comprehensive assessment. We then discuss behavioral and pharmacologic management strategies. Heterogeneity of stroke remains a challenge in management and new research is still needed to optimize and personalize treatments for stroke survivors.
DOI	10.1016/j.pmr.2023.06.028
PubMed ID	38514230