Weill Cornell Medicine
Citigroup Biomedical Imaging Center
Weill Cornell Medicine
Citigroup Biomedical Imaging Center

Periodontal disease as a possible cause for Alzheimer's disease.

Publication Type Review
Authors Kamer A, Craig R, Niederman R, Fortea J, de Leon M
Journal Periodontol 2000
Volume 83
Issue 1
Pagination 242-271
Date Published 06/01/2020
ISSN 1600-0757
Keywords Alzheimer Disease, Periodontal Diseases
Abstract Approximately 47 million people worldwide have been diagnosed with dementia, 60%-80% of whom have dementia of the Alzheimer's disease type. Unfortunately, there is no cure in sight. Defining modifiable risk factors for Alzheimer's disease may have a significant impact on its prevalence. An increasing body of evidence suggests that chronic inflammation and microbial dysbiosis are risk factors for Alzheimer's disease. Periodontal disease is a chronic inflammatory disease that develops in response to response to microbial dysbiosis. Many studies have shown an association between periodontal disease and Alzheimer's disease. The intent of this paper was to review the existing literature and determine, using the Bradford Hill criteria, whether periodontal disease is causally related to Alzheimer's disease.
DOI 10.1111/prd.12327
PubMed ID 32385876
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