Publication Type Academic Article
Authors Kamer A, Pushalkar S, Gulivindala D, Butler T, Li Y, Annam K, Glodzik L, Ballman K, Corby P, Blennow K, Zetterberg H, Saxena D, de Leon M
Journal Alzheimers Dement (Amst)
Volume 13
Issue 1
Pagination e12172
Date Published 04/12/2021
ISSN 2352-8729
Abstract INTRODUCTION: Periodontal disease is a chronic, inflammatory bacterial dysbiosis that is associated with both Alzheimer's disease (AD) and Down syndrome. METHODS: A total of 48 elderly cognitively normal subjects were evaluated for differences in subgingival periodontal bacteria (assayed by 16S rRNA sequencing) between cerebrospinal fluid (CSF) biomarker groups of amyloid and neurofibrillary pathology. A dysbiotic index (DI) was defined at the genus level as the abundance ratio of known periodontal bacteria to healthy bacteria. Analysis of variance/analysis of covariance (ANOVA/ANCOVA), linear discriminant effect-size analyses (LEfSe) were used to determine the bacterial genera and species differences between the CSF biomarker groups. RESULTS: At genera and species levels, higher subgingival periodontal dysbiosis was associated with reduced CSF amyloid beta (Aβ)42 (P = 0.02 and 0.01) but not with P-tau. DISCUSSION: We show a selective relationship between periodontal disease bacterial dysbiosis and CSF biomarkers of amyloidosis, but not for tau. Further modeling is needed to establish the direct link between oral bacteria and Aβ.
DOI 10.1002/dad2.12172
PubMed ID 33869725
PubMed Central ID PMC8040436
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