Publication Type Academic Article
Authors de Leon M, Ferris S, George A, Christman D, Fowler J, Gentes C, Reisberg B, Gee B, Emmerich M, Yonekura Y, Brodie J, Kricheff I, Wolf A
Journal AJNR Am J Neuroradiol
Volume 4
Issue 3
Pagination 568-71
Date Published 01/01/1983
ISSN 0195-6108
Keywords Aging, Alzheimer Disease, Dementia, Tomography, Emission-Computed
Abstract In this study the positron emission tomographic (PET)-18F-2-deoxy-2-fluoro-D-glucose (FDG) technique was used to study both normal aging and senile dementia. The results derived from 15 young normal subjects (mean age, 26 +/- 5 years) and 22 elderly normal subjects (mean age, 66 +/- 7 years) failed to indicate significant metabolic changes associated with age. A group of 24 patients with senile dementia (mean age, 73 +/- 7 years) showed consistent diminutions in regional glucose use relative to the elderly normals. Across all brain regions the diminutions were 17%-24%. There were also significant correlations between the measures of glucose use and the measures of cognitive functioning. Discriminant function classification analysis results indicate that better than 80% classification accuracy can be achieved for individual PET measures. These data suggest a possible future diagnostic use of PET in senile dementia.
PubMed ID 6410799
PubMed Central ID PMC8334899
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