Prelimbic cortex drives discrimination of non-aversion via amygdala somatostatin interneurons.
| Publication Type | Academic Article |
| Authors | Stujenske J, O'Neill P, Fernandes-Henriques C, Nahmoud I, Goldburg S, Singh A, Diaz L, Labkovich M, Hardin W, Bolkan S, Reardon T, Spellman T, Salzman C, Gordon J, Liston C, Likhtik E |
| Journal | Neuron |
| Volume | 110 |
| Issue | 14 |
| Pagination | 2258-2267.e11 |
| Date Published | 04/08/2022 |
| ISSN | 1097-4199 |
| Keywords | Amygdala, Basolateral Nuclear Complex |
| Abstract | The amygdala and prelimbic cortex (PL) communicate during fear discrimination retrieval, but how they coordinate discrimination of a non-threatening stimulus is unknown. Here, we show that somatostatin (SOM) interneurons in the basolateral amygdala (BLA) become active specifically during learned non-threatening cues and desynchronize cell firing by blocking phase reset of theta oscillations during the safe cue. Furthermore, we show that SOM activation and desynchronization of the BLA is PL-dependent and promotes discrimination of non-threat. Thus, fear discrimination engages PL-dependent coordination of BLA SOM responses to non-threatening stimuli. |
| DOI | 10.1016/j.neuron.2022.03.020 |
| PubMed ID | 35397211 |
| PubMed Central ID | PMC9308671 |