Prelimbic cortex drives discrimination of non-aversion via amygdala somatostatin interneurons.

Publication Type	Academic Article
Authors	Stujenske J, O'Neill P, Fernandes-Henriques C, Nahmoud I, Goldburg S, Singh A, Diaz L, Labkovich M, Hardin W, Bolkan S, Reardon T, Spellman T, Salzman C, Gordon J, Liston C, Likhtik E
Journal	Neuron
Volume	110
Issue	14
Pagination	2258-2267.e11
Date Published	04/08/2022
ISSN	1097-4199
Keywords	Amygdala, Basolateral Nuclear Complex
Abstract	The amygdala and prelimbic cortex (PL) communicate during fear discrimination retrieval, but how they coordinate discrimination of a non-threatening stimulus is unknown. Here, we show that somatostatin (SOM) interneurons in the basolateral amygdala (BLA) become active specifically during learned non-threatening cues and desynchronize cell firing by blocking phase reset of theta oscillations during the safe cue. Furthermore, we show that SOM activation and desynchronization of the BLA is PL-dependent and promotes discrimination of non-threat. Thus, fear discrimination engages PL-dependent coordination of BLA SOM responses to non-threatening stimuli.
DOI	10.1016/j.neuron.2022.03.020
PubMed ID	35397211
PubMed Central ID	PMC9308671