Publication Type Academic Article
Authors Ballon D, Jakubowski A, Tulipano P, Graham M, Schneider E, Aghazadeh B, Chen Q, Koutcher J
Journal Magn Reson Med
Volume 39
Issue 5
Pagination 789-800
Date Published 05/01/1998
ISSN 0740-3194
Keywords Algorithms, Bone Marrow, Hematopoiesis, Magnetic Resonance Imaging
Abstract Spatial maps of the percentage cellularity in pelvic bone marrow were calculated at a resolution of 15.6 mm3 from six volunteers and 10 patients treated for documented hematologic disease using a three-point Dixon MRI pulse sequence. The percentage cellularity calculation was aided by analyzing a two-dimensional feature space consisting of the apparent water fraction (Wa), and the T2 relaxation time of water (T2w). An extracellular water fraction was assigned to each voxel on the basis of a two-component T2w algorithm. In six cases, the method was compared to results obtained from core biopsies or aspirates of the posterior iliac crest. The results indicate that segmentation schemes that combine high-quality phase-contrast imaging with nuclear relaxation time measurements can potentially identify the true fractional marrow volume occupied by hematopoietic elements in a variety of clinical situations.
DOI 10.1002/mrm.1910390517
PubMed ID 9581611
Back to Top