Quantitative multimodal imaging in traumatic brain injuries producing impaired cognition.

Publication Type	Review
Authors	Shah S, Lowder R, Kuceyeski A
Journal	Curr Opin Neurol
Volume	33
Issue	6
Pagination	691-698
Date Published	12/01/2020
ISSN	1473-6551
Keywords	Brain, Brain Injuries, Traumatic, Cognition, Cognitive Dysfunction
Abstract	PURPOSE OF REVIEW: Cognitive impairments are a devastating long-term consequence following traumatic brain injury (TBI). This review provides an update on the quantitative mutimodal neuroimaging studies that attempt to elucidate the mechanism(s) underlying cognitive impairments and their recovery following TBI. RECENT FINDINGS: Recent studies have linked individual specific behavioural impairments and their changes over time to physiological activity and structural changes using EEG, PET and MRI. Multimodal studies that combine measures of physiological activity with knowledge of neuroanatomical and connectivity damage have also illuminated the multifactorial function-structure relationships that underlie impairment and recovery following TBI. SUMMARY: The combined use of multiple neuroimaging modalities, with focus on individual longitudinal studies, has the potential to accurately classify impairments, enhance sensitivity of prognoses, inform targets for interventions and precisely track spontaneous and intervention-driven recovery.
DOI	10.1097/WCO.0000000000000872
PubMed ID	33027143
PubMed Central ID	PMC7808369