Relationship Between Alzheimer Disease Imaging Biomarkers and Performance on the NIH Toolbox Cognition Battery in Late-middle Age Hispanics.

Publication Type	Academic Article
Authors	Tahmi M, Rippon B, Palta P, Sherwood G, Hernandez G, Soto L, Cespedes S, Pardo M, Laing K, Igwe K, Johnson A, Tomljanovic Z, He H, Gutierrez J, Teresi J, Moreno H, Kreisl W, Razlighi Q, Brickman A, Luchsinger J
Journal	Alzheimer Dis Assoc Disord
Volume	38
Issue	4
Pagination	311-318
Date Published	11/26/2024
ISSN	1546-4156
Keywords	Alzheimer Disease, Positron-Emission Tomography, Biomarkers, Hispanic or Latino, Magnetic Resonance Imaging
Abstract	PURPOSE: The National Institute of Health Toolbox Cognition Battery (NIHTB-CB) is increasingly used in Alzheimer disease (AD) research. We examined the relation of AD biomarkers with performance in the NIHTB-CB in late middle age. METHODS: This is a cross-sectional analysis of 334 Hispanic participants aged 64.22±3.35 years from a study of AD biomarkers. White matter hyperintensities (WMH), infarcts, and cortical thickness in AD regions (CT) were assessed with 3T magnetic resonance imaging. Amyloid and tau were assessed with 18F-Florbetaben and 18F-MK6240 positron emission tomography, respectively. RESULTS: Lower CT and infarcts were associated with worse Oral Reading Recognition and Cognition Crystallized Composite scores. Lower CT and higher WMH were associated with worse Pattern Comparison Processing Speed. Amyloid and tau were not associated with any test. DISCUSSION: Amyloid and tau, the culprits of AD, are not related to the NIHTB-CB in late middle age. Continued follow-up will reveal if AD impacts performance on the NIHTB-CB.
DOI	10.1097/WAD.0000000000000641
PubMed ID	39588688