Publication Type Academic Article
Authors Steffener J, Barulli D, Habeck C, O'Shea D, Razlighi Q, Stern Y
Journal PLoS One
Volume 9
Issue 3
Pagination e91196
Date Published 03/13/2014
ISSN 1932-6203
Keywords Aging, Cognition, Cognitive Reserve, Gray Matter, Verbal Behavior
Abstract Evidence suggests that individual variability in lifetime exposures influences how cognitive performance changes with advancing age. Brain maintenance and cognitive reserve are theories meant to account for preserved performance despite advancing age. These theories differ in their causal mechanisms. Brain maintenance predicts more advantageous lifetime exposures will reduce age-related neural differences. Cognitive reserve predicts that lifetime exposures will not directly reduce these differences but minimize their impact on cognitive performance. The present work used moderated-mediation modeling to investigate the contributions of these mechanisms at explaining variability in cognitive performance among a group of 39 healthy younger (mean age (standard deviation) 25.9 (2.92) and 45 healthy older adults (65.2 (2.79)). Cognitive scores were computed using composite measures from three separate domains (speed of processing, fluid reasoning, and memory), while their lifetime exposures were estimated using education and verbal IQ measures. T1-weighted MR images were used to measure cortical thickness and subcortical volumes. Results suggest a stronger role for cognitive reserve mechanisms in explaining age-related cognitive variability: even with age-related reduced gray matter, individuals with greater lifetime exposures could perform better given their quantity of brain measures.
DOI 10.1371/journal.pone.0091196
PubMed ID 24625888
PubMed Central ID PMC3953380
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