Publication Type Review
Authors Glodzik-Sobanska L, Rusinek H, Mosconi L, Li Y, Zhan J, de Santi S, Convit A, Rich K, Brys M, de Leon M
Journal Neuroimaging Clin N Am
Volume 15
Issue 4
Pagination 803-26, x
Date Published 11/01/2005
ISSN 1052-5149
Keywords Alzheimer Disease, Brain, Cognition Disorders, Magnetic Resonance Imaging, Tomography, X-Ray Computed
Abstract The goal of this article is to review the role of structural neuroimaging in the diagnosis of Alzheimer's disease (AD). We present relevant neuroanatomy, highlight progress in the domain of AD imaging, and review the clinical characteristics of the prodromal phase of AD. We describe the history of the diagnostic issue by examining at cross-section and longitudinally the differences between patients who have AD and normal controls. We also present how subsequent works applied these characteristic traits to the early detection of the prodromal disease and to prediction of future decline. The article delineates the differences between subjects who have mild cognitive impairment and AD, which illustrate the spreading of the pathology with disease progression. The last section describes problems encountered in the differential diagnosis.
DOI 10.1016/j.nic.2005.09.004
PubMed ID 16443492
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