The role of quantitative structural imaging in the early diagnosis of Alzheimer's disease.

Publication Type	Review
Authors	Glodzik-Sobanska L, Rusinek H, Mosconi L, Li Y, Zhan J, de Santi S, Convit A, Rich K, Brys M, de Leon M
Journal	Neuroimaging Clin N Am
Volume	15
Issue	4
Pagination	803-26, x
Date Published	11/01/2005
ISSN	1052-5149
Keywords	Alzheimer Disease, Brain, Cognition Disorders, Magnetic Resonance Imaging, Tomography, X-Ray Computed
Abstract	The goal of this article is to review the role of structural neuroimaging in the diagnosis of Alzheimer's disease (AD). We present relevant neuroanatomy, highlight progress in the domain of AD imaging, and review the clinical characteristics of the prodromal phase of AD. We describe the history of the diagnostic issue by examining at cross-section and longitudinally the differences between patients who have AD and normal controls. We also present how subsequent works applied these characteristic traits to the early detection of the prodromal disease and to prediction of future decline. The article delineates the differences between subjects who have mild cognitive impairment and AD, which illustrate the spreading of the pathology with disease progression. The last section describes problems encountered in the differential diagnosis.
DOI	10.1016/j.nic.2005.09.004
PubMed ID	16443492