Publication Type | Academic Article |
Authors | Boes A, Uitermarkt B, Albazron F, Lan M, Liston C, Pascual-Leone A, Dubin M, Fox M |
Journal | Brain Stimul |
Volume | 11 |
Issue | 3 |
Pagination | 575-581 |
Date Published | 01/31/2018 |
ISSN | 1876-4754 |
Keywords | Depressive Disorder, Major, Depressive Disorder, Treatment-Resistant, Gyrus Cinguli, Prefrontal Cortex, Transcranial Magnetic Stimulation |
Abstract | BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for medication-refractory major depression, yet the mechanisms of action for this intervention are poorly understood. Here we investigate cerebral cortex thickness as a possible biomarker of rTMS treatment response. METHODS: Longitudinal change in cortical thickness is evaluated relative to clinical outcomes across 48 participants in 2 cohorts undergoing left dorsolateral prefrontal cortex rTMS as a treatment for depression. RESULTS: Our results reveal changes in thickness in a region of the left rostral anterior cingulate cortex that correlate with clinical response, with this region becoming thicker in patients who respond favorably to rTMS and thinner in patients with a less favorable response. Moreover, the baseline cortical thickness in this region correlates with rTMS treatment response - those patients with thinner cortex before treatment tended to have the most clinical improvement. CONCLUSIONS: This study is the first analysis of longitudinal cortical thickness change with rTMS as a treatment for depression with similar results across two cohorts. These results support further investigation into the use of structural MRI as a possible biomarker of rTMS treatment response. |
DOI | 10.1016/j.brs.2018.01.029 |
PubMed ID | 29454551 |
PubMed Central ID | PMC6136654 |