Sex specificity of ventral anterior cingulate cortex suppression during a cognitive task.
| Publication Type | Academic Article |
| Authors | Butler T, Imperato-McGinley J, Pan H, Voyer D, Cunningham-Bussel A, Chang L, Zhu Y, Cordero J, Stern E, Silbersweig D |
| Journal | Hum Brain Mapp |
| Volume | 28 |
| Issue | 11 |
| Pagination | 1206-12 |
| Date Published | 11/01/2007 |
| ISSN | 1065-9471 |
| Keywords | Cognition, Emotions, Gyrus Cinguli, Prefrontal Cortex, Sex Characteristics |
| Abstract | Ventral anterior cingulate cortex (vACC) is a highly interconnected brain region considered to reflect the sometimes competing demands of cognition and emotion. A reciprocal relationship between vACC and dorsal ACC (dACC) may play a role in maintaining this balance between cognitive and emotional processing. Using functional MRI in association with a cognitively-demanding visuospatial task (mental rotation), we found that only women demonstrated vACC suppression and inverse functional connectivity with dACC. Sex differences in vACC functioning--previously described under conditions of negative emotion--are extended here to cognition. Consideration of participant sex is essential to understanding the role of vACC in cognitive and emotional processing. |
| DOI | 10.1002/hbm.20340 |
| PubMed ID | 17315226 |
| PubMed Central ID | PMC6871468 |