Publication Type | Academic Article |
Authors | He Q, Shungu D, van Zijl P, Bhujwalla Z, Glickson J |
Journal | J Magn Reson B |
Volume | 106 |
Issue | 3 |
Pagination | 203-11 |
Date Published | 03/01/1995 |
ISSN | 1064-1866 |
Keywords | Body Water, Lactates, Lipids, Mammary Neoplasms, Experimental |
Abstract | A novel single-scan selective homonuclear multiple-quantum coherence-transfer technique, Sel-MQC, is presented that achieves lactate editing with complete lipid and water suppression. The method is suitable for studying tissues with high fat content and those subject to substantial motion. Frequency-selective excitation is employed to selectively prepare lactate into its multiple-quantum states; lipid and water are left in the single-quantum modes and eliminated by the multiple-quantum selection gradients. The efficiency of lipid suppression is monitored by a 2D Sel-MQC experiment which separates lipid and lactate along the multiple-quantum-evolution dimension. The spatial distribution of lactate can be imaged by the spectroscopic imaging version of Sel-MQC. Sel-MQC sequences were demonstrated both in phantoms and in vivo, using subcutaneously implanted murine EMT6 tumors. |
DOI | 10.1006/jmrb.1995.1035 |
PubMed ID | 7719620 |