Publication Type Academic Article
Authors Reyes-Madrigal F, León-Ortiz P, Mao X, Mora-Durán R, Shungu D, de la Fuente-Sandoval C
Journal Arch Med Res
Volume 50
Issue 4
Pagination 207-213
Date Published 09/26/2019
ISSN 1873-5487
Keywords Glutathione, Proton Magnetic Resonance Spectroscopy, Psychotic Disorders
Abstract Deficits of brain glutathione (GSH), the most abundant and primary antioxidant in living tissue, and associated redox imbalance are postulated to be implicated in schizophrenia. This pilot clinical study compared the levels of striatal GSH, measured in vivo with proton magnetic resonance spectroscopy (1H MRS) at 3T, in 10 drug-naïve, first-episode psychosis (FEP) patients with those in 9 matched healthy control subjects. The results revealed a significant GSH deficit in FEP patients (0.92 ± 0.24 × 10-3) compared to the healthy control group (1.10 ± 0.10 × 10-3) (U = 25.00, p = 0.02), as well as a positive correlation between GSH levels and the Positive Symptoms subscale of the PANSS in the FEP group (ρ = 0.96; p <0.001). These preliminary findings suggest a possible role of striatal oxidative stress in early-stage psychosis that warrants further scrutiny and confirmation in larger studies.
DOI 10.1016/j.arcmed.2019.08.003
PubMed ID 31499481
PubMed Central ID PMC10624128
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