Publication Type | Academic Article |
Authors | Waterhouse N, Kothari P, Dooley M, Hu B, de Leon M, Babich J, Qu W |
Journal | Appl Radiat Isot |
Volume | 159 |
Pagination | 109078 |
Date Published | 02/08/2020 |
ISSN | 1872-9800 |
Abstract | A facile synthesis method for the preparation of [1-11C]butanol, a regional cerebral blood flow imaging agent, was developed. Using a solid phase extraction method, the highly polar and volatile molecule [1-11C]butanol was quickly concentrated, purified, and released as final product; boasting high radiochemical and chemical purities as well as high radiochemical yields. The final drug product was obtained as a sterile, pyrogen-free solution that conforms United States Pharmacopeia (USP) <823> requirements. |
DOI | 10.1016/j.apradiso.2020.109078 |
PubMed ID | 32068145 |