Publication Type Academic Article
Authors Waterhouse N, Kothari P, Dooley M, Hu B, de Leon M, Babich J, Qu W
Journal Appl Radiat Isot
Volume 159
Pagination 109078
Date Published 02/08/2020
ISSN 1872-9800
Abstract A facile synthesis method for the preparation of [1-11C]butanol, a regional cerebral blood flow imaging agent, was developed. Using a solid phase extraction method, the highly polar and volatile molecule [1-11C]butanol was quickly concentrated, purified, and released as final product; boasting high radiochemical and chemical purities as well as high radiochemical yields. The final drug product was obtained as a sterile, pyrogen-free solution that conforms United States Pharmacopeia (USP) <823> requirements.
DOI 10.1016/j.apradiso.2020.109078
PubMed ID 32068145
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