Publication Type | Academic Article |
Authors | Kamer A, Craig R, Pirraglia E, Dasanayake A, Norman R, Boylan R, Nehorayoff A, Glodzik L, Brys M, de Leon M |
Journal | J Neuroimmunol |
Volume | 216 |
Issue | 1-2 |
Pagination | 92-7 |
Date Published | 09/19/2009 |
ISSN | 1872-8421 |
Keywords | Alzheimer Disease, Antibodies, Periodontitis, Tumor Necrosis Factor-alpha |
Abstract | The associations of inflammation/immune responses with clinical presentations of Alzheimer's disease (AD) remain unclear. We hypothesized that TNF-alpha and elevated antibodies to periodontal bacteria would be greater in AD compared to normal controls (NL) and their combination would aid clinical diagnosis of AD. Plasma TNF-alpha and antibodies against periodontal bacteria were elevated in AD patients compared with NL and independently associated with AD. The number of positive IgG to periodontal bacteria incremented the TNF-alpha classification of clinical AD and NL. This study shows that TNF-alpha and elevated numbers of antibodies against periodontal bacteria associate with AD and contribute to the AD diagnosis. |
DOI | 10.1016/j.jneuroim.2009.08.013 |
PubMed ID | 19767111 |
PubMed Central ID | PMC2783848 |