Weill Cornell Medicine
Citigroup Biomedical Imaging Center
Weill Cornell Medicine
Citigroup Biomedical Imaging Center

TNF-alpha and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects.

Publication Type Academic Article
Authors Kamer A, Craig R, Pirraglia E, Dasanayake A, Norman R, Boylan R, Nehorayoff A, Glodzik L, Brys M, de Leon M
Journal J Neuroimmunol
Volume 216
Issue 1-2
Pagination 92-7
Date Published 09/19/2009
ISSN 1872-8421
Keywords Alzheimer Disease, Antibodies, Periodontitis, Tumor Necrosis Factor-alpha
Abstract The associations of inflammation/immune responses with clinical presentations of Alzheimer's disease (AD) remain unclear. We hypothesized that TNF-alpha and elevated antibodies to periodontal bacteria would be greater in AD compared to normal controls (NL) and their combination would aid clinical diagnosis of AD. Plasma TNF-alpha and antibodies against periodontal bacteria were elevated in AD patients compared with NL and independently associated with AD. The number of positive IgG to periodontal bacteria incremented the TNF-alpha classification of clinical AD and NL. This study shows that TNF-alpha and elevated numbers of antibodies against periodontal bacteria associate with AD and contribute to the AD diagnosis.
DOI 10.1016/j.jneuroim.2009.08.013
PubMed ID 19767111
PubMed Central ID PMC2783848
Back to Top