Publication Type Academic Article
Authors Kamer A, Craig R, Pirraglia E, Dasanayake A, Norman R, Boylan R, Nehorayoff A, Glodzik L, Brys M, de Leon M
Journal J Neuroimmunol
Volume 216
Issue 1-2
Pagination 92-7
Date Published 09/19/2009
ISSN 1872-8421
Keywords Alzheimer Disease, Antibodies, Periodontitis, Tumor Necrosis Factor-alpha
Abstract The associations of inflammation/immune responses with clinical presentations of Alzheimer's disease (AD) remain unclear. We hypothesized that TNF-alpha and elevated antibodies to periodontal bacteria would be greater in AD compared to normal controls (NL) and their combination would aid clinical diagnosis of AD. Plasma TNF-alpha and antibodies against periodontal bacteria were elevated in AD patients compared with NL and independently associated with AD. The number of positive IgG to periodontal bacteria incremented the TNF-alpha classification of clinical AD and NL. This study shows that TNF-alpha and elevated numbers of antibodies against periodontal bacteria associate with AD and contribute to the AD diagnosis.
DOI 10.1016/j.jneuroim.2009.08.013
PubMed ID 19767111
PubMed Central ID PMC2783848
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