Publication Type Academic Article
Authors Ballon D, Jakubowski A, Gabrilove J, Graham M, Zakowski M, Sheridan C, Koutcher J
Journal Magn Reson Med
Volume 19
Issue 1
Pagination 85-95
Date Published 05/01/1991
ISSN 0740-3194
Keywords Bone Marrow, Magnetic Resonance Imaging
Abstract Volume-localized proton NMR spectroscopy was used to estimate bone marrow cellularity in the posterior iliac crests of patients undergoing treatment with hematopoietic growth factors for a variety of hematologic and neoplastic disorders. Twelve patients were accrued, six of whom were studied more than once, yielding a total of 25 measurements. These data were compared to cellularity assessments derived from conventional bone marrow core biopsies obtained within a 24-h period before or after the NMR exam. The results obtained by the two methods are well correlated (R = 0.94, P less than 0.001), suggesting that this noninvasive technique may preclude the need for biopsies in some cases.
DOI 10.1002/mrm.1910190108
PubMed ID 2046540
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