Publication Type	Academic Article
Authors	Ballon D, Jakubowski A, Gabrilove J, Graham M, Zakowski M, Sheridan C, Koutcher J
Journal	Magn Reson Med
Volume	19
Issue	1
Pagination	85-95
Date Published	05/01/1991
ISSN	0740-3194
Keywords	Bone Marrow, Magnetic Resonance Imaging
Abstract	Volume-localized proton NMR spectroscopy was used to estimate bone marrow cellularity in the posterior iliac crests of patients undergoing treatment with hematopoietic growth factors for a variety of hematologic and neoplastic disorders. Twelve patients were accrued, six of whom were studied more than once, yielding a total of 25 measurements. These data were compared to cellularity assessments derived from conventional bone marrow core biopsies obtained within a 24-h period before or after the NMR exam. The results obtained by the two methods are well correlated (R = 0.94, P less than 0.001), suggesting that this noninvasive technique may preclude the need for biopsies in some cases.
DOI	10.1002/mrm.1910190108
PubMed ID	2046540