Publication Type Academic Article
Authors Butler T, Blackmon K, Zaborszky L, Wang X, DuBois J, Carlson C, Barr W, French J, Devinsky O, Kuzniecky R, Halgren E, Thesen T
Journal J Int Neuropsychol Soc
Volume 18
Issue 1
Pagination 157-61
Date Published 12/09/2011
ISSN 1469-7661
Keywords Memory, Septum of Brain
Abstract Septal nuclei, components of basal forebrain, are strongly and reciprocally connected with hippocampus, and have been shown in animals to play a critical role in memory. In humans, the septal forebrain has received little attention. To examine the role of human septal forebrain in memory, we acquired high-resolution magnetic resonance imaging scans from 25 healthy subjects and calculated septal forebrain volume using recently developed probabilistic cytoarchitectonic maps. We indexed memory with the California Verbal Learning Test-II. Linear regression showed that bilateral septal forebrain volume was a significant positive predictor of recognition memory accuracy. More specifically, larger septal forebrain volume was associated with the ability to recall item source/context accuracy. Results indicate specific involvement of septal forebrain in human source memory, and recall the need for additional research into the role of septal nuclei in memory and other impairments associated with human diseases.
DOI 10.1017/S1355617711001421
PubMed ID 22152217
PubMed Central ID PMC3339258
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