Volumetric measurement of the hippocampus, the anterior cingulate cortex, and the retrosplenial granular cortex of the rat using structural MRI.
| Publication Type | Academic Article |
| Authors | Wolf O, Dyakin V, Vadasz C, de Leon M, McEwen B, Bulloch K |
| Journal | Brain Res Brain Res Protoc |
| Volume | 10 |
| Issue | 1 |
| Pagination | 41-6 |
| Date Published | 08/01/2002 |
| ISSN | 1385-299X |
| Keywords | Brain Mapping, Gyrus Cinguli, Hippocampus, Lateral Ventricles, Magnetic Resonance Imaging, Rats, Sprague-Dawley |
| Abstract | MRI imaging of the rodent brain is a rapidly growing field in the neurosciences. Relatively limited information is available for regional volume determination. The present paper describes a reliable method for the assessment of the hippocampus, the anterior cingulate cortex, the retrosplenial granular cortex and the ventricles in rats. MRI scans were acquired using a 7 T magnet. The anatomical sampling method was found to be highly reliable with an intra-rater reliability of greater than 0.93. The current protocol should facilitate future in vivo neuroimaging research using animal models of neurodegenerative diseases. |
| DOI | 10.1016/s1385-299x(02)00181-2 |
| PubMed ID | 12379436 |