Volumetric measurement of the hippocampus, the anterior cingulate cortex, and the retrosplenial granular cortex of the rat using structural MRI.

Publication Type	Academic Article
Authors	Wolf O, Dyakin V, Vadasz C, de Leon M, McEwen B, Bulloch K
Journal	Brain Res Brain Res Protoc
Volume	10
Issue	1
Pagination	41-6
Date Published	08/01/2002
ISSN	1385-299X
Keywords	Brain Mapping, Gyrus Cinguli, Hippocampus, Lateral Ventricles, Magnetic Resonance Imaging, Rats, Sprague-Dawley
Abstract	MRI imaging of the rodent brain is a rapidly growing field in the neurosciences. Relatively limited information is available for regional volume determination. The present paper describes a reliable method for the assessment of the hippocampus, the anterior cingulate cortex, the retrosplenial granular cortex and the ventricles in rats. MRI scans were acquired using a 7 T magnet. The anatomical sampling method was found to be highly reliable with an intra-rater reliability of greater than 0.93. The current protocol should facilitate future in vivo neuroimaging research using animal models of neurodegenerative diseases.
DOI	10.1016/s1385-299x(02)00181-2
PubMed ID	12379436